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KMID : 0360220140550091366
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Journal of the Korean Ophthalmological Society
2014 Volume.55 No. 9 p.1366 ~ p.1371
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The Effects of Commodified Growth Factor Products on the Fibrovascularization of Porous Polyethylene Orbital Implants
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Gu Won-Mo
Choi Joon-Hyuk
Son Jun-Hyuk
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Abstract
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Purpose: To investigate the effects of commodified growth factor products used clinically on fibrovascular ingrowth into porous polyethylene orbital implants.
Methods: Porous polyethylene orbital implant sheets (Medporⓡ) soaked with Nepidermin (Easyefⓡ), Trafermin (Fiblastⓡ), and normal saline were implanted into the backs of 18 Sprague-Dawley rats. The degree of fibrovascular ingrowth as observed using a light microscope was compared 1 and 2 weeks after implantation and was calculated as a percentage of the fibrovascular ingrowth length.
Results: One week after implantation, the percentage of fibrovascular ingrowth length was 25.33 ± 5.43%, 22.56 ± 5.30%, and 21.78 ± 4.66% in the Easyefⓡ-, Fiblastⓡ- and normal saline-soaked groups. The degree of fibrovascularization was higher in the Easyefⓡ-soaked group than in the other groups (p = 0.020, 0.012). Two weeks after implantation, the degree of fibrovascularization was 98.33 ± 5.00%, 100.00 ± 0.00%, and 95.89 ± 4.57%, which was significantly higher in the Easyefⓡ-, and Fiblastⓡ-soaked groups than in normal saline-soaked group (p = 0.019, <0.001).
Conclusions: Commodified growth factor products used in other areas selectively enhanced fibrovascular ingrowth to a greater degree and earlier in ophthalmic plastic and reconstructive surgery.
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KEYWORD
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Basic fibroblast growth factor, Epidermal growth factor, Fibrovascularization, Porous polyethylene orbital implant
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